THE VERY BASIC GUIDE TO GHRP/GHRH PEPTIDES
THE VERY BASIC GUIDE TO GHRP/GHRH PEPTIDES

THE VERY BASIC GUIDE TO GHRP/GHRH PEPTIDES

Posted on

The newish supplement to be used by Bodybuilders are Peptides that naturally pulse GH from the body, the problem is that many make it all to confusing much more than it needs to be so i thought it would be a good article to write to try and clear some of the confusion on the subject.

if you prefer the science and long boring words to describe things this article is not for you 🙂 so here is a very basic guide, it does not contain any real detail to the science behind the need etc……

you need to look at 2 types of peptides:
GHRP – this group’s main types are GHRP-2, GHRP-6, Ipamorelin, Hexarelin (there are others but these are the most common and effective)
GHRH – this groups main type is Mod GRF 1-29 (sometimes called CJC1295 without DAC)

What do they do:
They release and amplify a natural pulse of GH from your body
GHRP release a pulse of GH
GHRH release and amplify this pulse
Combining both peptides gives more than double the effect of either alone due to the synergy they have it would be foolish in my opinion to use either alone.

GHRP in detail:

GHRP-6:
Growth hormone releasing peptide-6 (GHRP-6) is in the category of drugs known as GH Secretagogues. This category of drugs includes GHRP-2, GHRP-6, Ipamorelin, and Hexarelin. Their primary function is to stimulate the pituitary gland to produce more Growth Hormone. GHRPs have a 2-fold mechanism of action, in that they cause an increase in GH through amplifying the natural growth hormone releasing hormone (GHRH) signal transduction pathway, as well as by suppressing the actions of somatostatin.
GHRP-6 is a 1st generation GHRP and is primarily used in the BB’ing community for two reasons, which are 1) GH release and 2) Appetite stimulation. If one is considering using this peptide for GH release, the individual should consider whether or not the accompanying appetite stimulation is a beneficial or negative characteristic in their current circumstances. In individuals who struggle with appetite issues and have trouble eating enough food to meet their daily caloric requirements, this peptide can prove to be a great addition to their program. For those on contest diets or who are trying to lean out, they may want to forego this peptide in exchange for a GHRP absent of this effect.

Common benefits of GH (GHRP-6) include:

* Reductions in body fat
* Increased lean mass.
* Increased collagen production
* Improved sleep
* Increased cellular repair
* An increase in IGF-1
* Increases in bone density

Common side effects of GH (GHRP-6) include:

* Water retention
* Tightness and/or carpel tunnel-like symptoms in the wrist/hand.
* Numbness and tingling in the extremities
* A decrease in insulin sensitivity
* Tiredness

Recommendations for use:

* GHRP-6 should be administered on an empty stomach. No food should be consumed for 15-20 minutes post-inject, if maximum GH release is desired.
* When using GHRP-6 for GH release, the average dosing range is between 100-150 mcg per inject. Dosing frequency is between 1-4X per day.
* In order to elicit maximal elevations in GH, GHRP-6 should be combined with a GHRH, such as ModGRF1-29 (also known as CJC1295 w/o dac).
* If used for appetite stimulation, the common dosing range for GHRP-6 is between 100-300 per inject, as needed.

GHRP-2:

Growth hormone releasing peptide-2 (GHRP-2) is in the category of drugs known as GH secretagogues. This category of drugs includes GHRP-2, GHRP-6, Ipamorelin, and Hexarelin. Their primary function is to stimulate the pituitary gland to produce more growth hormone. GHRPs have a 2-fold mechanism of action, in that they cause an increase in GH through amplifying the natural growth hormone releasing hormone (GHRH) signal transduction pathway, as well as by suppressing the actions of somatostatin.

GHRP-2 is a 2nd generation GHRP and finds its primary use in the area of GH release. It is superior to GHRP-6 in this regard and is currently the preferred peptide for attaining maximum elevations in GH over the long-term. Recent research also reveals that GHRP-2 can be dosed much higher than initially thought, while avoiding the desensitization that is inherent in some of our other GHRP’s. This provides the user with the opportunity to experience greater elevations in total GH, depending on the dosage administered. Lastly, while GHRP-2 can potentially lead to some degree appetite stimulation, not all users experience this effect and when they do, it is typically much less profound in comparison to GHRP-6.

Common benefits of GH (GHRP-2) include:

* Decreases in body fat
* An increase in lean mass
* Increased collagen production
* Improved sleep
* Increased cellular repair
* An increase in IGF-1
* Increases in bone density

Common side effects of GH (GHRP-2) include:

* Water retention
* Tightness and/or carpel tunnel-like symptoms
* Numbness and tingling in the extremities
* A decrease insulin sensitivity
* Tiredness

Recommendations for use:
* GHRP-2 should be administered on an empty stomach. No food should be consumed for 15-20 minutes post-inject, if maximum GH release is desired.

* The average dosing range is between 100-2,000 mcg per inject. Dosing frequency is as little as 3X per week when mega-dosing…and up to 6X per day when using lower dosages. Multiple daily doses will yield the best results.

* In order to elicit maximal elevations in GH, GHRP-2 should be combined with a GHRH, such as ModGRF1-29 (also known as CJC1295 w/o dac).

Ipamorelin:
Ipamorelin is in the category of drugs known as GH secretagogues. This category of drugs includes GHRP-2, GHRP-6, Ipamorelin, and Hexarelin. Its primary function is to stimulate the pituitary gland to produce more growth hormone. Like the other GHRPs, it has a 2-fold mechanism of action, in that it causes an increase in GH through amplifying the natural growth hormone releasing hormone (GHRH) signal transduction pathway, as well as by suppressing the actions of Somatostatin.

Ipamorelin is a 3rd generation GHRP which displays great selectivity in its actions. Ipamorelin will not lead to any degree of appetite stimulation, will not affect prolactin or cortisol, and is used solely for GH release. On a mcg to mcg basis, its strength is comparable to GHRP-6, but unlike GHRP-6, it can be dosed much higher, resulting in potentially greater elevations in GH. Similar to GHRP-2, IPA has no ceiling dose. Therefore, as the dosage of IPA is titrated upward, GH release will continue to rise accordingly. Ipamorelin has developed a reputation as the “cleanest” of the GHRP’s and rightfully so.

Common benefits of GH (Ipamorelin) include:

* Decreases in body fat
* An increase in lean mass
* Increased collagen production
* Improved sleep
* Increased cellular repair
* An increase in IGF-1
* Increases in bone density

Common side effects of GH (Ipamorelin) include:

* Water retention
* Tightness and/or carpel tunnel-like symptoms
* Numbness and tingling in the extremities
* A decrease in insulin sensitivity
* Tiredness

Recommendations for use:

* Ipamorelin should be administered on an empty stomach. No food should be consumed at least 15-20 minutes post-inject, if maximum GH release is desired.

* The average dosing range is between 100-2,000 mcg per inject. Dosing frequency is as little as 3X per week when mega-dosing…and up to 4X per day when using lower dosages.

* In order to elicit maximal elevations in GH, IPA should be combined with a GHRH, such as ModGRF1-29 (also known as CJC1295 w/o dac).

Hexarelin:
Hexarelin is in the category of drugs known as GH secretagogues. This category of drugs includes GHRP-2, GHRP-6, Ipamorelin, and Hexarelin. Its primary function is to stimulate the pituitary gland to produce more growth hormone. Like the other GHRPs, it has a 2-fold mechanism of action, in that it causes an increase in GH through amplifying the natural growth hormone releasing hormone (GHRH) signal transduction pathway, as well as by suppressing the actions of Somatostatin.

Hexarelin, on a mcg per mcg basis, is the most potent of the GHRP’s for GH release. However, Hexarelin administration will quickly lead to desensitization when used at effective dosages, which makes it less than ideal for long-term use. This limitation has led to a decrease in popularity among users of GH peptides, with GHRP-2 and Ipamorelin leading the pack in the area of long-term effectiveness. However, these limitations do not mean Hexarelin is worthless. On the contrary, Hexarelin can be added to other GHRP’s (such as GHRP-2 & Ipamorelin) in lower dosages, in order to elicit further elevations in GH without incurring the desensitization that commonly presents itself when using Hex alone at peak effective dosages.

Common benefits of GH (Ipamorelin) include:

* Decreases in body fat
* An increase in lean mass
* Increased collagen production
* Improved sleep
* Increased cellular repair
* An increase in IGF-1
* Increases in bone density

Common side effects of GH (Ipamorelin) include:

* Water retention
* Tightness and/or carpel tunnel-like symptoms
* Numbness and tingling in the extremities
* A decrease in insulin sensitivity
* Tiredness

Recommendations for use:

* Hexarelin should be administered on an empty stomach. No food should be consumed at least 15-20 minutes post-inject, if maximum GH release is desired.
* The average dosing range is between 100-150 mcg per inject. Dosing frequency is between 1-4X per day.
* In order to elicit maximal elevations in GH, Hexarelin should be combined with a GHRH, such as ModGRF1-29 (also known as CJC1295 w/o dac).

* In order to avoid the rapid desensitization that typically accompanies Hexarelin use, it can be added to GHRP-2 and/or Ipamorelin at a dosage of 100 mcg 2-3 X per day. If this practice is limited to every other day usage, Hex can be used long-term, while increasing GH levels beyond what is normally experienced when using average doses of GHRP-2 or Ipamorelin.

GHRP-6 is sloppy in that it activates a wider array of effects beyond GH release. It causes intense hunger and gastic motility. It can have a mild effect on cortisol and prolactin. It is a first generation GHRP.

GHRP-2 is less sloppy with a more intense GH release, no gastric motility and less hunger effect. It can have an effect within the normal range on prolcatin and cortisol. It is a second generation peptide.

Hexarelin is not sloppy like GHRP-2 it gives a higher GH pulse but has some Gastric motility although no issues with hunger, you have to cycle the use of this peptide to avoid desensitisation though.

Ipamorelin is not sloppy at all. It does not release as much GH as GHRP-2 but it causes virtually no hunger or gastric motility and for the most part does not effect cortisol or prolactin. It is a third generation peptide

You would choose GHRP-2 unless you wanted GHRP-6 for the hunger effect or for the lower release profiles.

You would choose GHRP-2 or Hexarelin normally as the most bang for the buck, although Hexarelin will disturb REM sleep so long term GHRP-2 is the better choice out of all 4 GHRP peptides.

If you are very sensitive to perturbations in cortisol or prolactin you would choose the more expensive Ipamorelin.